Current Research

COVID-19 Published Articles by UAB Faculty

Associations between self-reported symptoms of SARS-CoV-2 and dietary supplement use over the previous year during the first pandemic wave February 1, 2023
During the initial wave of the COVID-19 pandemic, symptoms of infection varied widely among adults younger than 60 years. This cross-sectional investigation of adults ages 18-59 years explored associations between SARS-CoV-2 symptomatology and supplementation of micronutrients involved in immune function, such as multivitamins, vitamin D, vitamin C, vitamin E and zinc. Between August and December […]
Amy Ellis
Symptom duration and resolution with early outpatient treatment of convalescent plasma for COVID- 19: a randomized trial February 1, 2023
CONCLUSIONS: In this trial of outpatients with early COVID-19, CCP was not associated with faster resolution of symptoms compared to control. Overall, there were no differences in the prevalence of each symptom or symptom clusters at day 14 by treatment.
Sheriza Baksh
Risk of COVID-19 Infection in Long-term Survivors of Blood or Marrow Transplantation: A BMTSS Report February 1, 2023
There is limited information regarding COVID-19 in long-term blood or marrow transplant (BMT) survivors. We leveraged the BMT Survivor Study (BMTSS) to address this gap. BMTSS included patients who underwent BMT at one of three US sites between 1974 and 2014 and survived ≥2 years after BMT. A sibling cohort serves as a non-BMT comparison […]
Emily E Johnston
The SARS-CoV-2 Spike S1 Protein Induces Global Proteomic Changes in ATII-Like Rat L2 Cells that are attenuated by Hyaluronan January 31, 2023
The COVID-19 pandemic continues to impose a major impact on global health and economy since its identification in early 2020, causing significant morbidity and mortality worldwide. Caused by the SARS-CoV-2 virus, along with a growing number of variants, COVID-19 has led to 651,918,402 confirmed cases, and 6,656,601 deaths worldwide (as of December 27, 2022; https://covid19.who.int/). […]
James A Mobley
Targeting intracellular Neu1 for Coronavirus Infection Treatment January 30, 2023
There are currently no effective therapies for COVID-19 or antivirals against SARS-CoV-2 and vaccines appear less effective against new SARS-CoV-2 variants; thus, there is an urgent need to understand better the virulence mechanisms of SARS-CoV-2 and the host response to develop therapeutic agents. Herein, we show that host Neu1 regulates coronavirus replication by controlling sialylation […]
Darong Yang
Annals On Call - Outpatient Treatment of COVID-19 January 30, 2023
No abstract
Robert M Centor
Editorial: Frontiers in oral health: Highlights in preventive dentistry 2021/2 January 27, 2023
No abstract
Yasmi O Crystal
Development of COVID-19 Vaccines-An Unanticipated Moon Shot Achieved at Warp Speed January 23, 2023
No abstract
Michael S Saag
Severe acute respiratory syndrome coronaviruses contributing to mitochondrial dysfunction: Implications for post-COVID complications January 23, 2023
Mitochondria play a central role in oxidative phosphorylation (OXPHOS), bioenergetics linked with ATP production, fatty acids biosynthesis, calcium signaling, cell cycle regulation, apoptosis, and innate immune response. Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infection manipulates the host cellular machinery for its survival and replication in the host cell. The infectiaon causes perturbed the cellular metabolism […]
Shama Prasada Kabekkodu
COVID-19 bacteremic co-infection is a major risk factor for mortality, ICU admission, and mechanical ventilation January 23, 2023
CONCLUSIONS: Elevated neutrophil-to-lymphocyte ratio is a prognostic indicator of COVID-19 bacterial co-infection within 48-h of admission. Community-acquired bacterial co-infection, as defined by blood culture-positive results, confers greater increased risk of in-hospital mortality, ICU admission, and mechanical ventilation than previously described risk factors (advanced age, select comorbidities, male sex) for COVID-19 mortality, and is independent of […]
Michael John Patton
Impact of Severe Acute Respiratory Syndrome Coronavirus 2 Variants on Short- and Mid-term Cardiac Outcomes in Multisystem Inflammatory Syndrome in Children January 23, 2023
Cardiac outcomes of 131 children with multisystem inflammatory syndrome (MIS-C) were examined. The majority of the cohort was male (66.4%) and half were Black (49.6%). Cardiac involvement was evident in 25% of the cohort at diagnosis. Favorable short- and mid-term outcomes were documented on follow-up, irrespective of the severe acute respiratory syndrome coronavirus 2 variants […]
Swetha Pinninti
Rapid Development of an Integrated Network Infrastructure to Conduct Phase 3 COVID-19 Vaccine Trials January 23, 2023
CONCLUSIONS AND RELEVANCE: This Special Communication describes the design, geographic distribution, and underlying principles of conduct of these efficacy trials and summarizes data from 136 382 prospectively followed-up participants, including more than 2500 with documented COVID-19. These successful efforts can be replicated for other important research initiatives and point to the importance of investments in […]
Alfredo J Mena Lora
Impact of Human Coronavirus Infections on Paediatric Patients at a Tertiary Paediatric Hospital: A Retrospective Study of the Prepandemic Era January 22, 2023
CONCLUSION: HCoVs are important respiratory pathogens in the paediatric population, especially patients
Abdulsalam O Alsulami
Timely Resolution of SARS-CoV-2-Related Multi-System Inflammatory Syndrome in Children January 21, 2023
Background: Multisystem inflammatory syndrome in children (MIS-C) is a severe, postinfectious manifestation of coronavirus disease 2019 (COVID-19) in the pediatric population. The disease is manifested by hyperinflammation and can result in cardiac dysfunction, coronary changes, and end-organ damage. Adequate timely treatment can prevent poor outcomes in the short term, but long-term data is lacking. Methods: […]
Daniel D Reiff
Magnetic Resonance Imaging (MRI) Findings in COVID-19 Associated Encephalitis January 17, 2023
We conducted this study to investigate the scope of the MRI neuroimaging manifestations in COVID-19-associated encephalitis. From January 2020 to September 2021, patients with clinical diagnosis of COVID-19-associated encephalitis, as well as concomitant abnormal imaging findings on brain MRI, were included. Two board-certified neuro-radiologists reviewed these selected brain MR images, and further discerned the abnormal […]
Manoj Tanwar
Hypercholesterolemia After Coronavirus Disease-19 (COVID-19): Time to Include Lipoprotein X among the Differential Diagnoses January 16, 2023
CONCLUSION: In patients with complicated courses of COVID-19, LpX overaccumulation should be considered when a routine lipid panel shows significant LDL-C elevations. Awareness among healthcare providers regarding LpX is important to avoid unnecessary work-up and treatment.
Jennifer Girard
Intranasal Carbetocin Reduces Hyperphagia, Anxiousness and Distress in Prader-Willi Syndrome: CARE-PWS Phase 3 Trial January 12, 2023
CONCLUSIONS: Carbetocin was well tolerated, and the 3.2 mg dose was associated with clinically meaningful improvements in hyperphagia and anxiousness and distress behaviors in participants with PWS.
Elizabeth Roof
Role of Visit Modality in the HIV-Related No-Shows During the COVID-19 Pandemic: A Multisite Retrospective Cohort Study January 12, 2023
The emergence of the COVID-19 pandemic necessitated rapid expansion of telehealth as part of healthcare delivery. This study compared HIV-related no-shows by visit type (in-person; video; telephone) during the COVID-19 pandemic (April 2020-September 2021) from the Data for Care Alabama project. Using all primary care provider visits, each visit's outcome was categorized as no-show or […]
Maira Sohail
American College of Radiology Paid Family/Medical Leave Policy: A Call to Action for the House of Medicine January 12, 2023
Background: The American College of Radiology (ACR) passed a historic paid family/medical leave (PFML) resolution at its April 2022 meeting, resolving that "diagnostic radiology, interventional radiology, radiation oncology, medical physics, and nuclear medicine practices, departments and training programs strive to provide 12 weeks of paid family/medical leave in a 12-month period for its attending physicians, […]
Elizabeth Kagan Arleo
Effectiveness of mRNA-1273 vaccination against SARS-CoV-2 omicron subvariants BA.1, BA.2, BA.2.12.1, BA.4, and BA.5 January 12, 2023
Studies have reported reduced natural SARS-CoV-2 infection- and vaccine-induced neutralization against omicron BA.4/BA.5 compared with earlier omicron subvariants. This test-negative case-control study evaluates mRNA-1273 vaccine effectiveness (VE) against infection and hospitalization with omicron subvariants. The study includes 30,809 SARS-CoV-2 positive and 92,427 SARS-CoV-2 negative individuals aged ≥18 years tested during 1/1/2022-6/30/2022. While 3-dose VE against […]
Hung Fu Tseng